Proposal for a national registry to monitor women with Turner syndrome seeking assisted reproductive technology

Angela E. Lin, M.D., Megan F. Karnis, M.D., Laurel Calderwood, M.S., C.G.C., Melissa Crenshaw, M.D., Ami Bhatt, M.D., Irene Souter, M.D., Michael Silberbach, M.D., Richard H. Reindollar, M.D.

Volume 105, Issue 6, Pages 1446-1448


Many women with Turner syndrome (TS) are eager to become pregnant. A small number (5%–10%) will have a spontaneous pregnancy, an outcome thought to be more likely in women with mosaicism (1). The increased availability of oocyte donation (OD) through assisted reproductive technology (ART) has enabled an unknown number of women with TS to achieve a pregnancy. A gathering body of evidence, however, suggests that pregnancy is high risk, secondary to potential aortic dissection and rupture and a significant risk of developing hypertensive disorders of pregnancy.

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