Conjugated bisphenol A in maternal serum in relation to miscarriage risk

Conjugated bisphenol A level in maternal serum at the time of missed menses is associated with increased risk of euploid and aneuploid miscarriage in an infertile population.

Ruth B. Lathi, M.D., Cara A. Liebert, M.D., Kathleen F. Brookfield, M.D., Ph.D., Julia A. Taylor, Ph.D., Frederick S. vom Saal, Ph.D., Victor Y. Fujimoto, M.D., Valerie L. Baker, M.D.

Volume 102, Issue 1, Pages 123–128


To examine the relationship between the maternal serum bisphenol A (BPA) concentration at the time of the missed menstrual cycle and miscarriage risk.

Retrospective cohort of prospectively collected serum samples.

Academic fertility center.

Women presenting for early pregnancy monitoring with singleton pregnancies.

Stored serum samples from 4 to 5 weeks’ gestation analyzed for conjugated serum BPA concentrations.

Main Outcome Measure(s):
Live birth, miscarriage, and chromosome content of miscarriage.

With the 115 women included in the study, there were 47 live births and 68 clinical miscarriages (46 aneuploid and 22 euploid). Median conjugated BPA concentrations were higher in the women who had miscarriages than in those who had live births (0.101 vs. 0.075 ng/mL). Women with the highest quartile of conjugated BPA had an increased relative risk of miscarriage (1.83; 95% CI, 1.14–2.96) compared with the women in the lowest quartile. We found a similar increase risk for both euploid and aneuploid miscarriages.

Maternal conjugated BPA was associated with a higher risk of aneuploid and euploid miscarriage in this cohort. The impact of reducing individual exposure on future pregnancy outcomes deserves further study.

  • Lauren Johnson

    Very well done analysis with data that I find both interesting and potentially
    disturbing, especially given the ubiquitous nature of BPA in our environment. Do
    the authors plan to pursue this research further? Also, given the short half
    life of BPA in serum, are there other ways to measure BPA that are more
    representative of long-term exposure?

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