A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility

Capsule:
Overweight patients with infertility who underwent weight loss counseling and achieved meaningful weight loss (10%) had improved live birth rates compared with those who did not.

Authors:
Jonathan D. Kort, M.D., Caitlin Winget, M.S.E., Sun H. Kim, M.D., Ruth B. Lathi, M.D.

Volume 101, Issue 5, Pages 1400–1403

Abstract:

Objective:
To determine if meaningful weight loss (≥10%) improved conception and live birth rates of overweight patients with infertility.

Design:
A retrospective cohort study.

Setting:
Academic medical center.

Patient(s):
Overweight patients (body mass index ≥25 kg/m2; n = 52) being treated for infertility and referred for weight loss counseling.

Intervention(s):
Patients were given a “meaningful” weight loss goal of 10%. They were followed by an endocrinologist who provided diet and exercise recommendations, metabolic screening, and pharmacologic intervention when indicated.

Main Outcome Measure(s):
Pregnancy rate, live birth rate, weight loss.

Result(s):
Thirty-two percent of the patients achieved meaningful weight loss. Patients achieving meaningful weight loss had significantly higher conception (88% vs. 54%) and live birth rates (71% vs. 37%) than those who did not.

Conclusion(s):
Weight loss improves live birth rates in overweight patients with infertility. Health care providers should incorporate weight loss counseling when caring for overweight patients who plan to conceive.

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