Semen quality of consecutive ejaculates from cancer patients for fertility preservation

Capsule:
This is the first study showing that repeated ejaculates from cancer patients did not show substantial variation in semen quality.

Authors:
Seul Ki Kim, M.D., Jang Mi Lee, B.S., Byung Chul Jee, M.D., Ph.D., Chang Suk Suh, M.D., Ph.D., Seok Hyun Kim, M.D., Ph.D.

Volume 102, Issue 4, Pages 1124-1129

Abstract:

Objective:
To study variations in semen parameters among cancer patients who visited a sperm banking clinic before undergoing cancer treatment.

Design:
Retrospective, consecutive study.

Setting:
University-based hospital.

Patient(s):
Eighty-six patients, diagnosed with various cancers, undergoing multiple semen collections on 5 consecutive days, for fertility preservation, between 2004 and 2013.

Intervention(s):
None.

Main Outcome Measures:
Within- and between-subject coefficients of variation were estimated using a random-effects analysis of variance to assess the consistency of semen parameters (volume, sperm concentration, motility, rapid motility, total motile sperm count, and computer-based sperm parameters), whereas intraclass correlation coefficients (ICCs) were calculated to assess the size of the between-component of variance relative to the total component of variance.

Result(s):
When analyzing semen parameters over a maximum of 5 consecutive days, only the semen volume was significantly reduced in day-1 and -3 samples compared with the first sample. Almost all of the parameters showed high ICC values, suggesting that within-subject fluctuations were small relative to the between-subject variability. The highest ICC values were noted in volume (ICC 0.76; 95% confidence interval [CI] 0.52–0.89), followed by total motile count (ICC 0.71; 95% CI 0.30–0.89); the least consistent measure was wobble (ICC 0.14; 95% CI −0.13, 0.51).

Conclusion(s):
Repeated ejaculates from cancer patients did not show substantial variation in semen quality.

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