Association of kinase insert domain containing receptor KDR gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women

Capsule:
The kinase insert domain-containing receptor 604T/C polymorphism is associated with recurrent spontaneous abortion (RSA) in Korean women, whereas the 1719A/T polymorphism that is associated with RSA in Taiwanese Han women is not associated with RSA in Korean women.

Authors:
Hyung Chul Rah, D.V.M., Ph.D., Young Joo Jeon, M.S., Bo Eun Lee, B.S., Dong Hee Choi, M.D., Ph.D., Tae Ki Yoon, M.D., Ph.D., Woo Sik Lee, M.D., Ph.D., Nam Keun Kim, Ph.D.

Volume 99, Issue 3, Pages 753-760.e8, 1 March 2013

Abstract:

Objective:
To investigate whether kinase insert domain-containing receptor (KDR) gene polymorphisms are risk factors for recurrent spontaneous abortion (RSA) in Korean women.

Design:
Case-control study.

Setting:
University hospital.

Patient(s):
Three hundred twenty-seven idiopathic RSA patients and 230 controls with Korean ethnicity.

Intervention(s):
None.

Main Outcome Measure(s):
The KDR -604T>C (rs2071559), 1192G>A (rs2305948), and 1719A>T (rs1870377) polymorphisms were assessed.

Result(s):
KDR -604TC and TC+CC genotypes were more prevalent in RSA patients than in controls (adjusted odds ratio [AOR]=2.091 and 2.076, respectively). KDR -604TC+CC/1192GG, – 604TC+CC/1719AA, and -604TC+CC/1719TA+TT combined genotypes exhibited higher frequencies in RSA patients (AOR=2.422, 2.611, and 2.216, respectively). KDR -604C/1192G/1719A, -604C/1192G/1719T, -604C/1192G, -604C/1719A, and -604C/1719T haplotype frequencies were higher in RSA patients (OR=1.778, 2.659, 2.089, 1.678, and 1.806, respectively), whereas – 604T/1192G/1719A, -604T/1192G, and -604T/1719A haplotype frequencies were lower in RSA patients (OR=2.422, 2.611, and 2.216, respectively). No association was found between RSA and KDR 1192G>A or 1719A>T.

Conclusion(s):
An association between the KDR -604T>C polymorphism and RSA was found in Korean women. Carriers of the -604C variant allele were more frequent among RSA patients than controls, suggesting that KDR -604C may confer RSA risk. The association of 1719A>T with RSA that was found in Taiwanese Han women was not observed in Korean women.

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