Fertility and Sterility 50 years ago today

Author:
Martin Kathrins, M.D.

Volume 105, Issue 1, Page 44

Abstract:

MacLeod J, Pazianos A, Ray B. The restoration of human spermatogenesis and of the reproductive tract with urinary gonadotropins following hypophysectomy. Fertil Steril 1966:17(1): 7–23.

“No precedent was available in the male for the amount of [human menopausal gonadotropin] to be given in order to initiate spermatogenesis, if the latter could be done at all.”

“In this experiment, the evidence is strongly in favor of FSH activity being exerted first at the level of the spermatogonium, inducing mitosis and proliferation of this cell.”

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