Fertility Pregnancy and Medical Management of Turner Syndrome in the Reproductive Years

Capsule:
Women with Turner syndrome are at high risk of maternal and fetal morbidity and mortality. Fertility preservation may be an option for some girls. They also require lifelong comprehensive screening.

Author:
Megan Freebury Karnis, M.D.

Volume 98, Issue 4, Pages 787-791, October 2012

Abstract:
Turner syndrome results in infertility in the majority of cases. Fertility preservation through the cryopreservation of oocytes or ovarian tissue may be an option for some girls with Turner syndrome. Oocyte donation results in high pregnancy rates. Those who plan to pursue pregnancy need comprehensive screening and counseling before and after conception. Pregnancies conceived with either autologous or donated oocytes are at high risk of maternal death from aortic dissection/rupture and are at high risk of serious hypertensive disorders. Reproductive aged women with Turner syndrome require ongoing screening for associated medical conditions unrelated to reproduction.

  • This review is one of the most important sources of informing us about the care of Turner`s syndrome patients. In relation to the high miscarriage rate, it is not only important in conception with own oocyte but also in cases of oocyte donation. The miscarriage rate in Turner syndrome patients is as high as 40-60%, probably owing to a uterine factor.Unfortunately the majority of the studies published reported a low number of patients. The article is very informative and shows a complete evaluation of patients with Turner Syndrome.

  • laurenwroth

    This is another excellent review on Turner’s syndrome. I think the most surprising statistic (that I was previously unaware of) is the high rate of chromosomal abnormalities in the offspring of women with Turner syndrome (conceived with autologous oocytes). Because most with Turner syndrome are diagnosed at latest in the mid teen years, it seems of utmost importance that the patients and families be counseled on reproductive options and risks starting shortly after diagnosis.

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