Preconceptional thyroid stimulating hormone levels and outcomes of intrauterine insemination among euthyroid infertile women

Capsule:
Among euthyroid patients undergoing IUI, TSH level was not associated with cycle parameters or clinical pregnancy rate. TSH level was inversely related to the odds of spontaneous abortion.

Authors:
Anatte E. Karmon, M.D., Maria Batsis, M.D., Jorge E. Chavarro, M.D., Sc.D., Irene Souter, M.D.

Volume 103, Issue 1, Pages 258-263

Abstract:

Objective:
To evaluate differences in intrauterine insemination (IUI) outcomes among euthyroid women with preconceptional thyroid-stimulating hormone (TSH) values in the normal (0.4–2.4 mIU/L) and high-normal (2.5–4.9 mIU/L) ranges.

Design:
Cohort study.

Setting:
A single fertility center.

Patient(s):
A total of 1,477 women who underwent 4,064 IUI cycles between the years 2004 and 2012.

Intervention(s):
None.

Main Outcome Measure(s):
Live birth, clinical pregnancy, spontaneous abortion (SAB), and IUI cycle parameters.

Result(s):
Cycles were categorized into 4 groups based on preconceptional TSH values: 0.40–1.36 mIU/L; 1.37–1.86 mIU/L; 1.87–2.49 mIU/L; and 2.50–4.99 mIU/L. No statistically significant differences were found in IUI cycle parameters, clinical pregnancy rates, or live births per initiated cycle among the 4 TSH groups. However, preconceptional TSH was inversely related to SAB and positively related to live birth among women who achieved a clinical pregnancy. In this group of women, cycles with TSH values between 2.5 and 4.9 mIU/L were related to lower odds of SAB (odds ratio: 0.32; 95% confidence interval: 0.16–0.65) and higher odds of live birth (odds ratio: 2.80; 95% confidence interval: 1.43–5.48) compared with cycles among women in the lowest TSH group.

Conclusion(s):
Among euthyroid patients, preconceptional TSH values in the high-normal range (between 2.5 and 4.9 mIU/L) are not associated with adverse IUI outcomes.

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