MicroRNA A step beyond bulk seminal parameters

Authors:
James M. Hotaling, M.D., M.S., Timothy G. Jenkins, Ph.D.

Volume 104, Issue 3, Page 554

Abstract:

Reflections on “Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile” by Salas-Huetos et al.

  • Great editorial stressing the need to look beyond semen analysis. Unfortunately, SA is the best test we have to predict fertility outcomes but has so much variability both within an individual and dependent upon laboratory and sometimes technology (CASA). DNA fragmentation, sperm aneuploidy and now micro-RNA are tests that help us with information beyond the SA – where and when should these tests be used remains the holy grail.

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