In vitro maturation of oocytes Uncommon indications

In vitro maturation may be an attractive option in patients suffering from ovarian resistance to FSH and for preserving fertility in combination with ovarian tissue cryopreservation.

Michael Grynberg, M.D., Ph.D., Hady El-Hachem, M.D., Astrid de Bantel, M.D., Julie Benard, M.D., Soizic le Parco, M.D., Renato Fanchin, M.D., Ph.D.

Volume 99, Issue 5, Pages 1182-1188, April 2013


Retrieval of immature oocytes from unstimulated ovaries, followed by in vitro maturation (IVM) was initially proposed to avoid the risks and side effects of exogenous gonadotropin administration. Therefore, over the past decades, IVM was mainly offered in PCOS patients at high risk of ovarian hyperstimulation syndrome. However, the development of fertility preservation has recently open new perspectives in the field of IVM. The present review summarizes uncommon indications of IVM, which is a viable option to treat infertility in patients with ovarian resistance to FSH, but may also be considered to preserve fertility in leukemia as well as before ovarian transposition and endometrioma excision.

  • Thank you for this interesting review on IVM for uncommon indications. Are you planning to report / publish the two pregnancies in patients with resistance to FSH in more detail? What kind of IVM was used? Is anything known about what receptor defect they had?

    Also, you succinctly summarize the concept of preservation of immature oocytes in special populations such as patients with leukemia and endometriosis. The question here is whether there is a danger that patients reading this will choose fertility preservation of immature rather than mature oocytes even if success with IVM is limited to few specialized centers who report their results in the literature. What is your view on this?

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