Sperm vacuoles negatively affect outcomes in intracytoplasmic morphologically selected sperm injection in terms of pregnancy implantation and live birth rates and live birth rates

Capsule:
The presence of sperm vacuoles does not affect fertilization rate and embryo quality but significantly influences pregnancy, implantation, and live-birth rates.

Authors:
Ermanno Greco, M.D., Filomena Scarselli, M.Sc., Gemma Fabozzi, M.Sc., Alessandro Colasante, Ph.D., Erminia Alviggi, PhD., Katarzyna Litwicka, M.D., Maria Teresa Varricchio, M.D., Maria Giulia Minasi, M.Sc., Jan Tesarik, M.D.

Volume 100, Issue 2, Pages 379-385, August 2013

Abstract:

Objective:
To retrospectively evaluate whether sperm vacuoles influence clinical results, with a particular focus on live-birth rates, in 101 intracytoplasmic morphologically selected sperm injection (IMSI) cycles.

Design:
Retrospective, observational study.

Setting:
Medical center.

Patient(s):
A total of 101 couples with at least two failed intracytoplasmic sperm injection (ICSI) attempts and impaired sperm morphology.

Intervention(s):
Patients divided into two groups according to sperm morphology and vacuolization pattern: group A comprising patients with good quality spermatozoa (type I and/or type II spermatozoa) (n = 63 patients); group B comprising patients with low quality spermatozoa (type III and/or IV spermatozoa) (n = 38 patients).

Main Outcome Measure(s):
Fertilization rate, embryo quality, pregnancy, implantation, and live-birth rates.

Result(s):
No statistically significant differences were observed between group A and B with regard to “early” assisted reproduction outcomes (fertilization rate and embryo quality). However, the “late” outcomes (pregnancy, implantation, and live-birth rates) were statistically significantly higher in group A.

Conclusion(s):
These results confirm a correlation between sperm vacuoles and a negative IMSI outcome, suggesting that sperm vacuoles are related to the late paternal effect.

  • Michael Eisenberg

    This study supports the utility of IMSI by reporting higher pregnancy and live birth rates in couples having failed previous ICSI attempts. As the authors acknowledge in the introduction, there continues to be controversy surrounding the benefit of this technology. Certainly further studies are needed.

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