Utilization and success rates of unstimulated in vitro fertilization in the United States an analysis of the Society for Assisted Reproductive Technology database

Capsule:
This is the first report, based on the SART database, of utilization and outcomes of unstimulated (natural cycle) IVF in the United States. Natural cycle IVF should be considered as a therapy for infertile couples.

Authors:
John David Gordon, M.D., Michael DiMattina, M.D., Andrea Reh, M.D., Awie Botes, B.Sc., Gerard Celia, Ph.D., Mark Payson, M.D.

Volume 100, Issue 2, Pages 392-395, August 2013

Abstract:

Objective:
To examine the utilization and outcomes of natural cycle (unstimulated) IVF as reported to the Society of Assisted Reproductive Technology (SART) in 2006 and 2007.

Design:
Retrospective analysis.

Setting:
Dataset analysis from the SART Clinical Outcome Reporting System national database.

Patient(s):
All patients undergoing IVF as reported to SART in 2006 and 2007.

Intervention(s):
None.

Main Outcome Measure(s):
Utilization of unstimulated IVF; description of patient demographics; and comparison of implantation and pregnancy rates between unstimulated and stimulated IVF cycles.

Result(s):
During 2006 and 2007 a total of 795 unstimulated IVF cycles were initiated. Success rates were age dependent, with patients <35 years of age demonstrating clinical pregnancy rates per cycle start, retrieval, and transfer of 19.2%, 26.8%, and 35.9%, respectively. Implantation rates were statistically higher for unstimulated compared with stimulated IVF in patients who were 35 to 42 years old. Conclusion(s):
Unstimulated IVF represents <1% of the total IVF cycles initiated in the United States. The pregnancy and live birth rates per initiated cycle were 19.2% and 15.2%, respectively, in patients <35 years old. The implantation rates in unstimulated IVF cycles compared favorably to stimulated IVF. Natural cycle IVF may be considered in a wide range of patients as an alternative therapy for the infertile couple.

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