Intracytoplasmic sperm injection ICSI for non male factor infertility A committee opinion

This committee opinion assesses the literature, where available, to identify situations where intracytoplasmic sperm injection may be indicated in the absence of an identified male factor.

The Practice Committees of the American Society for Reproductive Medicine and Society for Assisted Reproductive Technology

Volume 98, Issue 6, Pages 1395-1399, December 2012


Intracytoplasmic sperm injection, while typically effective for overcoming low or absent fertilization in couples with a clear abnormality of semen parameters, is frequently utilized in combination with assisted reproductive technologies for other etiologies of infertility in the presence of normal semen parameters. This committee opinion provides a critical review of the literature, where available, to identify situations where this may or may not be of benefit.

  • people still get nervous with <6 oocytes and risk of failed fertilization, perhaps due to anecdotes from past experience…ultimately, ICSI for low oocyte yield is no different that conventional

  • Fernando Bronet, PhD

    This is an old and interesting debate that tries to find if there is or not evidence to
    perform ICSI in all indications. However we must take into account also the
    epigenetic errors, lately have been published several studies that show
    differences between ICSI and conventional IVF (Santos et al, 2010; Bridges et
    al, 2011).

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