Recommendations for gamete and embryo donation A committee opinion

Capsule:
This document provides the latest recommendations for evaluation of potential sperm, oocyte, and embryo donors.

Authors:
Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology

Volume 99, Issue 1, Pages 47-62.e1, January 2013

Abstract:
This document provides the latest recommendations for evaluation of potential sperm, oocyte, and embryo donors, incorporating recent information about optimal screening and testing for sexually transmitted infections (STIs), genetic diseases, and psychological assessments. This revised document incorporates recent information from the U.S. Centers for Disease Control and Prevention, the U.S. Food and Drug Administration (FDA), and the American Association of Tissue Banks (AATB), with which all programs offering gamete and embryo donation services must be thoroughly familiar, and replaces the document titled “2008 Guidelines for gamete and embryo donation: a Practice Committee report” last published in Fertility and Sterility 2008;90:S30- 44.

  • Kris Smith

    Is there a reputable sperm bank which uses criteria in screening and ongoing monitoring of the donors in a similarly stringent way as do oocyte donation centers? For example, the lack of mandatory personality testing and/or other more extensive psychological screening for sperm donors I have found extremely unfortunate. If there is no center that requires this kind of screening, what about a center that will provide such (more thorough) screening for an extra cost? Sperm donors, should, in my opinion, be just as thoroughly screened as an oocyte donor, medically, psychologically, etc.

    Also, are there scientifically valid, reliable source rankings of the various centers here in the U.S. that is recommended by the ASRM, which could include, preferably in table format: clear comparative analyses made available to potential recipients as to what standards are adhered to, as well as any standards that exceed — medical, psychological, clinical, ethical, other regulatory — current regulatory requirements in the respective juristiction; listings of any/all sanctions, investigations, probationary issues; and the like?

  • NicoGarrido

    ASRM recommendations are of undoubtful help as a reference guideline for international practice when describing situations not regulated yet.

    In this sense, this is valuable information in order to take decisions beyond what is legally required, being even more astringent, maintaining an equilibrioum between costs and benefits, on the basis of risk management.
    Interestingly, recommends CF in all donors but not karyotype.
    Also, the reccomendation of 25 livebirths per population of 800000 habitants is far from those regulations present in Europe. Given that the transmission of genetic diseases depend on the prevalence, the number of livebirths is not relevant for this issue (in fact, a good system to cut the donor’s use when a defect in the offspring is detected may improve these ratios). The limit should be established in order to diminish the risk of unknown consanguinity, and on the basis of common sense.

  • Fernando Bronet, PhD

    Guidelines are basic to start working in a clinic, particularly in the case of gamete or embryo donation. In this document is described that chromosomal analysis are not required, but in the appendix A we can see that the donor “should not have a known karyotype abnormality that result in chromosomally unbalanced gametes”. Perhaps we should perform that analysis for every donor.
    Regarding the limitations to donor use, it is suggested no more than 25 births per donor, according to the risk of inadvertent consanguineous conception. However, we should take into account the consequences of using a donor (gamete or embryo) with a serious genetic disease. As it is impossible to test all diseases we have to establish limits in order to avoid those consequences as have occurred in other countries.
    In other hand, there are enough data in the bibliography that show us that oocyte vitrification has very good results and we can use the technique if a quarantine of the oocites is required

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