The clinical utility of sperm DNA integrity testing A guideline

This document describes the basics of sperm DNA integrity; assesses the evidence pertaining to the clinical utility of sperm DNA integrity testing; and targets areas that require more study.

The Practice Committee of the American Society for Reproductive Medicine

Volume 99, Issue 3, Pages 673-677, 1 March 2013


Sperm DNA damage is more common in infertile men and may contribute to poor reproductive performance. However, current methods for assessing sperm DNA integrity do not reliably predict treatment outcomes and cannot be recommended routinely for clinical use.

  • Mike Hsieh

    DNA fragmentation index showed promising results to predict sperm function in small series. The lack of level 1 evidence has led to ASRM’s recommendation against routine testing. However, in selected cases(recurrent pregnancy lost/failed IVF cycles), I still believe that using testicular sperm can improve fertility outcomes in the setting of elevated DNA fragmentation(as shown in the literature and in my personal practice). Anybody else have similar experience?

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