Oocyte efficiency does live birth rate differ when analyzing cryopreserved and fresh oocytes on a per oocyte basis

Capsule:
The biological efficiency of oocyte cryopreservation is comparable to fresh in vitro fertilization when live-birth rate is analyzed per mature oocyte retrieved.

Authors:
Kara N. Goldman, M.D., Nicole L. Noyes, M.D., Jaime M. Knopman, M.D., Caroline McCaffrey, Ph.D., H.C.L.D., James A. Grifo, M.D., Ph.D.

Volume 100, Issue 3, Pages 712-717, September 2013

Abstract:

Objective:
To compare the efficiency of oocyte cryopreservation (OC) and IVF using the metric “live births per mature oocyte retrieved.”

Design:
Retrospective analysis.

Setting:
University-based fertility center.

Patient(s):
Forty women who underwent OC with thaw attempt between 2004 and 2010; 25 autologous and 15 donor-oocyte treatments were included. One thousand nine hundred eight women underwent their first, fresh conventional IVF treatment between 2004 and 2010; 1,392 used autologous oocytes, and 516 used donor oocytes. Autologous and donor-oocyte cycles were analyzed separately. All oocytes were obtained from women Intervention(s):
None.

Main Outcome Measure(s):
Live-birth rate per mature oocyte retrieved (primary outcome), live-birth rate per ET, and blastocyst formation rate.

Result(s):
When OC/thaw cycles were compared with fresh IVF attempts, there was no significant difference in live-birth rate per mature oocyte retrieved (2.7% vs. 4.2%, respectively) or live-birth rate per ET (45.8% vs. 51.9%). Significantly more oocytes were harvested in the OC versus fresh IVF cycles (21 vs. 16); however, fewer blastocysts developed (3.9 vs. 6.3). Thus, we noted an age-independent approximate twofold decrease in blastocyst formation in the OC group.

Conclusion(s):
Our data suggest that while assisted reproductive technology remains an inefficient process, OC may be approaching fresh IVF when live birth is the primary consideration. However, OC may negatively impact the potential for blastocyst formation.

  • Lauren Johnson

    Interesting paper comparing LBR among cycles utilizing fresh vs. cryopreserved oocytes. I agree with the authors that measuring LBR per mature oocyte retrieved may be a more useful measure of oocyte efficiency. The finding that blast formation rate is lower among cryopreserved embryos is an important finding that requires further investigation. Among oocyte cryopreservation cycles, did you notice differences in blast formation rate based on cryopreservation method?

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