Spermatogonial stem cell preservation in Klinefelter boys: to bank or not to bank, that’s the question
To date, retrieval of spermatogonial cells in prepubertal boys with Klinefelter syndrome should be viewed as experimental and patients and their parents must be counseled accordingly.
Inge Gies, M.D., Jean De Schepper, M.D., Ph.D., Ellen Goossens, Ph.D., Dorien Van Saen, M.Sc., Guido Pennings, Ph.D., Herman Tournaye, M.D., Ph.D.
Volume 98, Issue 2, Pages 284-289, August 2012
Although early development of testis appears normal in boys with Klinefelter syndrome (KS), spermatogonial stem cell (SSC) depletion occurs in mid puberty, leading to infertility. Therefore, freezing of semen samples or testicular tissue sampling could be offered to KS boys at onset of puberty. However, only in about half of KS patients, adult or prepubertal, spermatozoa or SSCs can be observed, and to date, no clinical parameters are available to detect patients who might benefit from these techniques. Furthermore, strategies for the further use of the cryopreserved material are still under investigation. Retrieval of spermatogonial cells in prepubertal KS boys should therefore still be viewed as experimental and patients and their parents must be counseled accordingly.