Experimental methods to preserve male fertility and treat male factor infertility

Capsule:
This article describes experimental stem cell and gene therapies that might be used to treat male factor infertility.

Authors:
Kathrin Gassei, Ph.D., Kyle E. Orwig, Ph.D.

Volume 105, Issue 2, Pages 256-266

Abstract:

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their families, and society, which extend far beyond the inability to have a biological child. Lifestyle changes, fertility treatments, and assisted reproductive technology (ART) are available to help many infertile couples achieve their reproductive goals. All of these technologies require that the infertile individual is able to produce at least a small amount of functional gametes (eggs or sperm). It is not possible for a person who does not produce gametes to have a biological child. This review focuses on the infertile man and describes several stem cell-based methods and gene therapy approaches that are in the research pipeline and may lead to new fertility treatment options for men with azoospermia.

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