Profiling the gene signature of endometrial receptivity Clinical Results

This contribution highlights the need for an objective diagnosis of endometrial factors to prevent reproductive failure that must be based on the genomic signature of endometrial receptivity.

Tamara Garrido-Gómez, Ph.D., María Ruiz-Alonso, Ph.D. student, David Blesa, Ph.D., Patricia Díaz-Gimeno, Ph.D., Felipe Vilella, Ph.D., Carlos Simón, Ph.D.

Volume 99, Issue 4, Pages 1078-1085, 15 March 2013


This article aims to highlight the need for methods to objectively diagnose endometrial receptivity as a factor contributing to infertility in female patients. The correct identification of the appropriate window of implantation in a given patient, by using endometrial receptivity biomarkers, can help to prevent reproductive failure resulting from misplaced timing of the endometrial window of implantation (WOI). Although to date no single, clinically relevant, morphological, molecular, or histological marker capable of indicating endometrial receptivity status has been identified, global transcriptomic analysis of human endometria performed in the last decade has given us insights into a genomic signature which is capable of identifying endometrial receptivity. As a consequence, a genomic tool named the Endometrial Receptivity Array (ERA), based on a customised microarray was developed, and along with it a specially trained bioinformatic prediction computer algorithm was created to identify WOI timing in the endometrium. This tool has proven more accurate and consistent than histological (Noyes) dating at identifying the personalised WOI day, thus leading to the new clinical concept of personalised embryo transfer (pET) on the optimum day of endometrial receptivity, identified individually case by case.

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