Endometrial reconstruction from stem cells

Capsule:
Adult stem cells have been identified in human endometrium. Their ability to reconstruct endometrial tissue when transplanted into immunocompromised animals suggests their potential use for treating disorders associated with inadequate endometrium.

Authors:
Caroline E. Gargett, Ph.D. and Louie Ye, Ph.D.
Volume 98, Issue 1 , Pages 11-20, July 2012

Abstract:
Adult stem cells have been identified in the highly regenerative human endometrium on the basis of their functional attributes. They can reconstruct endometrial tissue in vivo suggesting their possible use in treating disorders associated with inadequate endometrium. The identification of specific markers for endometrial mesenchymal stem cells and candidate markers for epithelial progenitor cells enables the potential use of endometrial stem/progenitor cells in reconstructing endometrial tissue in Asherman syndrome and intrauterine adhesions.

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