Protocols to induce ovulation and progesterone block experiments

Daniela Galliano, MD, PhD


Clomiphene citrate (CC) was an emerging area of research in the 1960s. It was first used to treat patients with oligomenorrhea, and later as a treatment for anovulation. The 1966 Fertility and Sterility article in which Whitelaw (1) reported its use in 217 women, related the indication of its use, dosage, side effects, and the hormonal changes that follow its administration. This contributed a general agreement on treatment, with CC established as an effective method of inducing ovulation and improving fertility in oligoovulatory patients.

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