Rescue intracytoplasmic sperm injection A systematic review

Capsule:
A literature search using the term “rescue ICSI” was performed. Thirty-eight studies were included, describing 1,863 patients and 194 offspring. Pregnancy rates and procedure safety are discussed.

Authors:
Ronit Beck-Fruchter, M.D., Michal Lavee, M.D., Amir Weiss, M.D., Yoel Geslevich, M.D., Eliezer Shalev, M.D.

Volume 101, Issue 3, Pages 690-698, March 2014

Abstract:

Objective:
To assess the feasibility, efficacy, and safety of rescue intracytoplasmic sperm injection (ICSI) in cases of fertilization failure, using a scientific literature search.

Design:
Systematic review.

Setting:
Centers for reproductive care.

Patient(s):
Infertility patients with total or partial fertilization failure during an IVF cycle.

Intervention(s):
An electronic literature search was performed in PubMed from 1992 through May 2013. The search was then expanded by using listed references from selected articles.

Main Outcome Measure(s):
Pregnancy rate. The secondary outcome measures were fertilization rate, normal fertilization rate, cleavage rate, birth rate, and malformation rate.

Result(s):
Thirty-eight studies including 1,863 patients were included. The pooled pregnancy rate was 14.4%; 194 babies were delivered.

Conclusion(s):
Rescue ICSI can result in the delivery of a healthy newborn, although the pregnancy rates are low. The clinical evidence did not indicate an elevated rate of malformations, although the data are limited and incomplete.

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