Aromatase inhibitors for subfertile women with polycystic ovary syndrome Summary of a Cochrane review

Letrozole appears to be superior to clomiphene citrate for ovulation induction in subfertile women with polycystic ovary syndrome.

Sebastian Franik, B.Sc., Jan A.M. Kremer, Ph.D., Willianne L.D.M. Nelen, Ph.D., Cynthia Farquhar, M.P.H., Jane Marjoribanks, M.P.H.

Volume 103, Issue 2, Pages 353-355


Polycystic ovary syndrome (PCOS) is a common cause of anovulatory subfertility. We evaluated the effectiveness and safety of aromatase inhibitors compared with other methods of ovulation induction in women with anovulatory PCOS.

  • Despite the evidence presented, there still appears to be a widespread hesitation to use Letrozole as a first-line treatment for ovulation induction in the US (given the past controversies / warnings etc). What are the practice patterns in other countries? And can it be expected that ASRM will at some point release a statement that Letrozole should be considered as first-line agent?

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