Aromatase inhibitors for subfertile women with polycystic ovary syndrome Summary of a Cochrane review

Capsule:
Letrozole appears to be superior to clomiphene citrate for ovulation induction in subfertile women with polycystic ovary syndrome.

Authors:
Sebastian Franik, B.Sc., Jan A.M. Kremer, Ph.D., Willianne L.D.M. Nelen, Ph.D., Cynthia Farquhar, M.P.H., Jane Marjoribanks, M.P.H.

Volume 103, Issue 2, Pages 353-355

Abstract:

Polycystic ovary syndrome (PCOS) is a common cause of anovulatory subfertility. We evaluated the effectiveness and safety of aromatase inhibitors compared with other methods of ovulation induction in women with anovulatory PCOS.

  • Despite the evidence presented, there still appears to be a widespread hesitation to use Letrozole as a first-line treatment for ovulation induction in the US (given the past controversies / warnings etc). What are the practice patterns in other countries? And can it be expected that ASRM will at some point release a statement that Letrozole should be considered as first-line agent?

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