Mild ovarian stimulation with clomiphene citrate launch is a realistic option for in vitro fertilization
Mild stimulation using clomiphene citrate can be considered a realistic option to give patients with a good prognosis an excellent probability of pregnancy in a very short time period.
Anna Pia Ferraretti, Ph.D., Luca Gianaroli, M.D., Maria Cristina Magli, M.Sc., Paul Devroey, Ph.D.
Volume 104, Issue 2, Pages 333-338
To validate the use of clomiphene citrate in IVF when mild stimulation approaches are chosen to reduce patient discomfort, risk, and cost.
Prospective cohort study.
Private IVF clinic.
A total of 163 patients undergoing IVF and with a good prognosis (defined as ≤38 years old with normal ovarian reserve and normovulatory cycles, body mass index
Mild stimulation using a fixed protocol of clomiphene citrate (100 mg/d from cycle days 3 to 7) in combination with low doses of gonadotropins (150 IU of recombinant FSH on cycle days 5, 7, and 9) and GnRH antagonist.
Main Outcome Measure(s):
The cumulative delivery rate per patient after three fresh and/or frozen embryo transfers and time to pregnancy.
No dropouts were observed. The cumulative delivery rate was 70%, and the mean time to pregnancy was 2.4 months.
Mild stimulation using clomiphene citrate in combination with low doses of gonadotropins can be considered a realistic option for good-prognosis patients undergoing IVF.