Mild ovarian stimulation with clomiphene citrate launch is a realistic option for in vitro fertilization

Capsule:
Mild stimulation using clomiphene citrate can be considered a realistic option to give patients with a good prognosis an excellent probability of pregnancy in a very short time period.

Authors:
Anna Pia Ferraretti, Ph.D., Luca Gianaroli, M.D., Maria Cristina Magli, M.Sc., Paul Devroey, Ph.D.

Volume 104, Issue 2, Pages 333-338

Abstract:

Objective:
To validate the use of clomiphene citrate in IVF when mild stimulation approaches are chosen to reduce patient discomfort, risk, and cost.

Design:
Prospective cohort study.

Setting:
Private IVF clinic.

Patient(s):
A total of 163 patients undergoing IVF and with a good prognosis (defined as ≤38 years old with normal ovarian reserve and normovulatory cycles, body mass index

Intervention(s):
Mild stimulation using a fixed protocol of clomiphene citrate (100 mg/d from cycle days 3 to 7) in combination with low doses of gonadotropins (150 IU of recombinant FSH on cycle days 5, 7, and 9) and GnRH antagonist.

Main Outcome Measure(s):
The cumulative delivery rate per patient after three fresh and/or frozen embryo transfers and time to pregnancy.

Result(s):
No dropouts were observed. The cumulative delivery rate was 70%, and the mean time to pregnancy was 2.4 months.

Conclusion(s):
Mild stimulation using clomiphene citrate in combination with low doses of gonadotropins can be considered a realistic option for good-prognosis patients undergoing IVF.

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