Ovulation induction and epigenetic anomalies
This systematic review summarizes the current knowledge about the potential epigenetic effects of ovulation induction during gametogenesis and also during implantation and postimplantation periods.
Patricia Fauque, M.D., Ph.D.
Volume 99, Issue 3, Pages 616-623, 1 March 2013
This systematic review reports the effects of ovulation induction on epigenetic control. Studies mainly done in the mouse model highlight that hormonal treatments may be per se prejudicial to the epigenetic reprogramming of the gametes as well as of the early embryos. Moreover, hormonal protocols used in assisted reproduction may also modify the physiological environment of the uterus potentially linked to endometrial epigenetic disturbances. Nowadays, the little data available in humans does not allow us to independently determine the impact of the woman’s age, infertility problems, protocols and doses of hormonal treatments on processes including genomic imprinting, and therefore emphasizes the need for further studies on humans.