Infertility fertility treatment and risk of hypertension

Capsule:
No increase occurred in hypertension risk over the long term among infertile women or those who underwent fertility treatment.

Authors:
Leslie V. Farland, Sc.M., Francine Grodstein, Sc.D., Serene S. Srouji, M.D., John P. Forman, M.D., M.Sc., Janet Rich-Edwards, Sc.D., Jorge E. Chavarro, M.D., Sc.D., Stacey A. Missmer, Sc.D.

Volume 104, Issue 2, Pages 391-397

Abstract:

Objective:
To evaluate the association between infertility and fertility treatments on subsequent risk of hypertension.

Design:
Cohort study.

Setting:
Not applicable.

Patient(s):
A total of 116,430 female nurses, followed from 1993 to June 2011, as part of the Nurses’ Health Study II cohort.

Intervention(s):
None.

Main Outcome Measure(s):
Self-reported, physician-diagnosed hypertension.

Result(s):
Compared with women who have never reported infertility, infertile women were at no greater risk of hypertension (multivariable adjusted relative risk (RR) = 1.01, with 95% confidence interval [CI] [0.94–1.07]). Infertility due to tubal disease was associated with a higher risk of hypertension (RR = 1.15 [1.01–1.31]), but no other diagnoses were associated with hypertension risk, compared with women who did not report infertility (ovulatory disorder: RR = 1.03 [0.94–1.13]; cervical: RR = 0.88 [0.70–1.10]; male factor: RR = 1.05 [0.95–1.15]; other reason: RR = 1.02 [0.94–1.11]; reason not found: RR = 1.02 [0.95–1.10]). Infertile women collectively had 5,070 cases of hypertension. No clear pattern between use of fertility treatment and hypertension was found among infertile women (clomiphene citrate: RR = 0.97 [0.90–1.04]; gonadotropin alone: RR = 0.97 [0.87–1.08]; intrauterine insemination: RR = 0.86 [0.71–1.03]; in vitro fertilization: RR = 0.86 [0.73–1.01]).

Conclusion(s):
Among this relatively young cohort of women, no apparent increase occurred in hypertension risk among infertile women, or among women who had undergone fertility treatment previously.

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