Oocyte in vitro maturation in normo ovulatory women

Capsule:
In normo-ovulatory women, in vitro maturation does not result in success rates similar to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.

Authors:
Rubens Fadini, M.D., Mario Mignini Renzini, M.D., Mariabeatrice Dal Canto, Ph.D., Amalia Epis, M.D., Marilena Crippa, B.Sc., Ilaria Caliari, M.D., Claudio Brigante, M.D., Giovanni Coticchio, Ph.D.

Volume 99, Issue 5, Pages 1162-1169, April 2013

Abstract:

Objective:
To review the scientific literature concerning the application of oocyte in vitro maturation (IVM) as a treatment for normo-ovulatory women.

Design:
To critically evaluate and compare the most relevant clinical studies.

Setting:
Public IVF unit.

Patients:
Normo-ovulatory women.

Intervention(s):
Oocyte in vitro maturation and cryopreservation.

Main outcome measures:
Maturation, fertilization, implantation, and pregnancy rates.

Results:
Maturation rates in vitro are suboptimal, but are influenced by several factors. In vitro matured oocytes fertilize and undergo development in vitro with rates comparable to in vivo matured controls. In IVM cycles, implantation and pregnancy rates are lower in comparison to controlled ovarian stimulation treatments, but accurate patient selection can improve IVM clinical outcome.

Conclusions:
In normal responders, IVM does not reach success rates comparable to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.

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