Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients

Capsule:
Vitamin D insufficiency or deficiency does not influence implantation and pregnancy rates in oocyte recipients.

Authors:
Alberta Fabris, M.D., Alberto Pacheco, Ph.D., María Cruz, Ph.D., Jose Manuel Puente, M.D., Human Fatemi, M.D., Juan A. Garcia-Velasco, M.D., Ph.D.

Volume 102, Issue 6, Pages 1608-1612

Abstract:

Objective:
To investigate the correlation between total and bioavailable serum 25-OH vitamin D and the pregnancy rate in recipients of donated oocytes.

Design:
Retrospective study.

Setting:
University-affiliated private IVF center.

Patient(s):
A total of 267 patients who were referred to our clinic for oocyte donation from June 2013 to December 2013.

Intervention(s):
Serum analysis of vitamin D and bioavailable vitamin D and reproductive outcomes.

Main Outcome Measure(s):
Pregnancy and implantation rate.

Result(s):
Among all patients, 15.3% (n = 41) were vitamin D replete (vitamin D >30 ng/mL), 50.2% (n = 134) had vitamin D deficiency (20–30 ng/mL), and 34.4% (n = 92) had insufficient vitamin D (

Conclusion(s):
Vitamin D insufficiency and deficiency are frequent conditions in our southern European infertile population. In contrast to previous studies, patients who are not vitamin D replete do not have a decreased chance of becoming pregnant with egg donation. Bioavailable 25-OH vitamin D, which is a better marker of the status than total 25-OH vitamin D, does not correlate with pregnancy rate in recipients of donated oocytes. Thus, at this stage, there is insufficient evidence to recommend vitamin D screening in patients undergoing egg donation.

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