Dietary fatty acid intakes and asthenozoospermia A case control study

Capsule:
The high intake of saturated and trans-fats was positively related to asthenozoospermia. Dietary omega-3 polyunsaturated fatty acids are dose dependently and inversely associated with reduced odds of asthenozoospermia.

Authors:
Ghazaleh Eslamian, M.Sc., Naser Amirjannati, M.D., Bahram Rashidkhani, M.D., Ph.D., Mohammad-Reza Sadeghi, Ph.D., Ahmad-Reza Baghestani, Ph.D., Azita Hekmatdoost, M.D., Ph.D.

Volume 103, Issue 1, Pages 190-198

Abstract:

Objective:
To investigate the association between dietary fatty acids intakes and asthenozoospermia.

Design:
Case-control study.

Setting:
Infertility clinics.

Patient(s):
A total of 107 men with incident asthenozoospermia and 235 age-matched controls.

Intervention(s):
None.

Main Outcome Measure(s):
Assessments of dietary intakes, semen quality, anthropometry, endocrine parameters, and demographic information.

Result(s):
According to the fully adjusted model, being in the highest tertile of total saturated fatty acids (odds ratio [OR] = 1.85, 95% confidence interval [CI] 1.24–2.96), total trans-fatty acids (OR = 2.53, 95% CI 1.54–3.92), palmitic acid (OR = 1.90, 95% CI 1.26–2.74), and stearic acid (OR = 2.13, 95% CI 1.29–3.88) was positively associated with asthenozoospermia. Whereas higher intakes of omega-3 polyunsaturated (OR = 0.68, 95% CI 0.58–0.94) and of docosahexaenoic (OR = 0.53, 95% CI 0.29–0.89) fatty acids were significantly associated with reduced odds of asthenozoospermia.

Conclusion(s):
Our findings suggest that the high intake of saturated and trans-fats was positively related to the odds of having asthenozoospermia. Conversely, inverse and dose-dependent associations were found between asthenozoospermia and intake of omega-3 polyunsaturated fatty acids. The observed associations of different types of fatty acids underline the importance of the type of fat in the etiology of asthenozoospermia.

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