Maternal body mass index and serum concentrations of human chorionic gonadotropin in very early pregnancy

Capsule:
High maternal BMI was associated with low serum hCG concentrations on day 16 after ovulation induction in 2,110 singleton and in 516 multiple pregnancies after ART.

Authors:
Anne Eskild, M.D., Ph.D., Peter Fedorcsak , M.D., Ph.D., Lars Mørkrid, M.D., Ph.D., Tom Tanbo, M.D., Ph.D.

Volume 98, Issue 4, Pages 905-910, October 2012

Abstract:

Objective:
To study the association of maternal pre-pregnancy body mass index (BMI) with serum concentrations of hCG in early pregnancy.

Design:
Cross-sectional study.

Setting:
Oslo University Hospital, Norway, 1996-2010.

Patients:
Among 3,301 pregnancies with live born offspring conceived after assisted reproduction treatment, 2,611 women had information of serum hCG concentrations on day 16 after ovulation induction and pre-pregnancy BMI: 2,110 mothers with singleton and 501 mothers with multiple pregnancy.

Interventions:
None

Main Outcome Measure:
Human chorionic gonadotropin concentration.

Results:
Geometric mean hCG concentration was higher in multiple pregnancies (190 IU/L) than in singleton pregnancies (106 IU/L). In singleton pregnancies geometric mean serum concentration decreased from 117 IU/L in women with BMI <20 kg/m2 to 86 IU/L in women with BMI ≥35 kg/m2. In multiple pregnancies, the corresponding decrease was from 226 IU/L to 130 IU/L. There was a significant negative association of BMI with hCG concentrations log transformed in the study sample as a whole (regression coefficient −0.013), in singleton pregnancies (regression coefficient −0.012), and in multiple pregnancies (regression coefficient −0.03). Conclusion:
Serum hCG concentrations were negatively associated with maternal prepregnancy BMI. One possible explanation may be an effect of adipose tissue-derived signalling molecules on hCG secretion by the implanting embryo.

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