A new chapter in the bisphenol A stor Bisphenol S and bisphenol F are not safe alternatives to this compound

Bisphenol S and bisphenol F, which are planned to replace bisphenol A, exhibit similar antiandrogenic effects than bisphenol A in cultured human and mouse testes.


Soria Eladak, M.Sc., Tiphany Grisin, M.Sc., Delphine Moison, M.Sc., Marie-Justine Guerquin, Ph.D., Thierry N’Tumba-Byn, Ph.D., Stéphanie Pozzi-Gaudin, M.D., Alexandra Benachi, M.D., Ph.D., Gabriel Livera, Ph.D., Virginie Rouiller-Fabre, Ph.D., René Habert, Ph.D.

Volume 103, Issue 1, Pages 11-21


Bisphenol A (BPA) is a widely studied typical endocrine-disrupting chemical, and one of the major new issues is the safe replacement of this commonly used compound. Bisphenol S (BPS) and bisphenol F (BPF) are already or are planned to be used as BPA alternatives. With the use of a culture system that we developed (fetal testis assay [FeTA]), we previously showed that 10 nmol/L BPA reduces basal testosterone secretion of human fetal testis explants and that the susceptibility to BPA is at least 100-fold lower in rat and mouse fetal testes. Here, we show that addition of LH in the FeTA system considerably enhances BPA minimum effective concentration in mouse and human but not in rat fetal testes. Then, using the FeTA system without LH (the experimental conditions in which mouse and human fetal testes are most sensitive to BPA), we found that, as for BPA, 10 nmol/L BPS or BPF is sufficient to decrease basal testosterone secretion by human fetal testes with often nonmonotonic dose-response curves. In fetal mouse testes, the dose-response curves were mostly monotonic and the minimum effective concentrations were 1,000 nmol/L for BPA and BPF and 100 nmol/L for BPS. Finally, 10,000 nmol/L BPA, BPS, or BPF reduced Insl3 expression in cultured mouse fetal testes. This is the first report describing BPS and BPF adverse effects on a physiologic function in humans and rodents.

  • Thomas J. Moore

    I agree completely with this article regarding BPA being a hormone disruptor. However we see 1700+ patients a year and have found many of them with other complications. As BPA levels increase it creates concurrant amounts of lactic acid, causing extremely tight muscles, headaches and body aches. I surmise this is why there are an inordinate number of soft tissue injures in sports. Extremely high levels effect liver function to the point of jaundice and excessive ammonia. We have also found that in the long term it will soften the skeletal system.
    BPF is actually worse in symptomology. I myself acquired it from coconut cream in a can. My thymus function dropped precipitously causing cold chills and severe uncontrollable shaking. Lactic acid levels went up with a very small amount of BFA causing a constant headache of level 4 to 5. My ANA increased creating blisters and nerve pain in the extremities and throat. A number of doses of Chelazyme from Biotics Research removed the BFA, however the symptoms are still lingering as of today, especially the blistering and nerve pain in the my extremities.
    My wife some had different symptoms in that her thymus was overactive causing welts, rash and itching on her chest and vagina.

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