Risk of transferring malignant cells with transplanted frozen thawed ovarian tissue
For some cancers, especially hematologic pathologies, transplanting frozen-thawed ovarian tissue can transfer malignant cells. This paper overviews this risk for different cancers.
Marie-Madeleine Dolmans, M.D., Ph.D., Valérie Luyckx, M.D., Jacques Donnez, M.D., Ph.D., Claus Yding Andersen, D.M.Sc., Tine Greve, M.D.
Volume 99, Issue 6, Pages 1514-1522, May 2013
Ovarian tissue cryopreservation and transplantation is a real option to preserve and restore fertility in young cancer patients. However, there is a concern regarding the possible presence of malignant cells in the ovarian tissue, which could lead to recurrence of the primary disease after reimplantation. A review of the existing literature was done to evaluate the risk of transplanting malignant cells in case of the main malignant indications for ovarian tissue cryopreservation. For ovarian tissue from patients with haematological malignancies, it is of primordial importance to identify minimal residual disease prior to ovarian tissue transplantation. Indeed, these pathologies, here reviewed in details, are considered the most at risk of ovarian metastasis.