Prognosis factors of pregnancy after intrauterine insemination with the husbands sperm Conclusions of an analysis of 2019 cycles

Capsule:
Positive predictive factors of pregnancy after IUI-H were woman’s secondary infertility, woman basal FSH levels 7 IU/L, ovulation triggering and inseminated progressive motile spermatozoa 1 million.

Authors:
Laka Dinelli, M.D., Blandine Courbiere, M.D., Ph.D., Vincent Achard, M.D., Ph.D., Elisabeth Jouve, M.Sc., Carole Deveze, M.D., Audrey Gnisci, M.D., Jean-Marie Grillo, M.D., Ph.D., Odile Paulmyer-Lacroix, M.D., Ph.D.

Volume 101, Issue 4, Pages 994-1000

Abstract:

Objective:
To identify the prognostic factors for pregnancy after intrauterine insemination with the husband’s sperm (IUI-H).

Design:
Retrospective study.

Setting:
A single university medical center.

Patient(s):
851 couples, for 2,019 IUI-H cycles.

Intervention(s):
After controlled ovarian stimulation, IUI-H performed 36 hours after ovulation triggering or 24 hours after a spontaneous luteinizing hormone (LH) surge.

Main Outcome Measure(s):
Clinical pregnancy rate per cycle (PR) and delivery rate per cycle (DR).

Result(s):
The overall PR was 14.8% and DR 10.8%. Higher PR and DR were observed for patients presenting with ovulation disorders (particularly polycystic ovary syndrome) or with male infertility. Secondary infertility in the woman appeared to be a positive prognostic factor as did a basal follicle-stimulating hormone (FSH) level ≤7 IU/L and ovulation triggering over spontaneous LH rise. The other parameters influencing the results were the women’s age, the number of mature follicles obtained (≥2), the endometrial thickness (10–11 mm), and the number of progressive motile spermatozoa inseminated (>1 million).

Conclusion(s):
In women aged ≤38 years, IUI-H should be considered as an option, particularly in cases of female infertility from ovulation disorders, in cases of a normal ovarian reserve, in cases of secondary infertility, or when ≥1 million progressive sperm are inseminated. Bifollicular stimulation is required. In other cases, in vitro fertilization should be discussed as the first-line treatment.

  • Ruby

    My daughter will be turning 5 in less than a month, and I am also preparing for my 4th IUI in Biotex clinic. I would never have thought that medicine in Ukraine can be on such level. I changed my mind after visiting this clinic. I like that in Ukraine the legal system is very loyal. They provide very good conditions even though this country is not so rich. I am hoping for a similar happy ending to a struggle with secondary infertility :). I know you’re living the reality of an almost 6 year age gap. And I’m only imagining what it will be like, but I feel strongly that we’re all adults for a long time and as we age life gets more complicated and it’s so nice to have siblings by your side. And the age gap will be nothing when they are 25 and beyond. I’m so happy that things worked out for you! It’s hard to find positive thoughts in the midst of infertility information. And your honesty yet reliance on your faith are a welcome change! “My God is big enough”. Yes, He is. Thank you for reminding me xoxo

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