Antimüllerian hormone Correlation with age and androgenic and metabolic factors in women from birth to postmenopause
Antimullerian hormone, which elevates from birth to 18 years of age and declines thereafter, is positively correlated with androgen levels in adolescent and reproductive-aged women.
Linlin Cui, M.D., Ph.D., Yingying Qin, M.D., Ph.D., Xuan Gao, M.D., Ph.D., Jun Lu, Ph.D., Ling Geng, Lingling Ding, M.D., Zhongyu Qu, M.D., Ph.D., Xiruo Zhang, M.D., Zi-Jiang Chen, M.D., Ph.D.
Volume 104, Issue 2, Pages 481-485
To study the age-specific distribution of antimüllerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages.
A total of 6,763 Chinese women from birth to menopause.
Main Outcome Measure(s):
Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles.
According to the level of AMH, four age phases were established: childhood (0–10 years), adolescence (11–18 years), reproductive age (19–50 years), and advanced age (≥51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = −0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase.
From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.