Antimüllerian hormone Correlation with age and androgenic and metabolic factors in women from birth to postmenopause

Capsule:
Antimullerian hormone, which elevates from birth to 18 years of age and declines thereafter, is positively correlated with androgen levels in adolescent and reproductive-aged women.

Authors:
Linlin Cui, M.D., Ph.D., Yingying Qin, M.D., Ph.D., Xuan Gao, M.D., Ph.D., Jun Lu, Ph.D., Ling Geng, Lingling Ding, M.D., Zhongyu Qu, M.D., Ph.D., Xiruo Zhang, M.D., Zi-Jiang Chen, M.D., Ph.D.

Volume 104, Issue 2, Pages 481-485

Abstract:

Objective:
To study the age-specific distribution of antimüllerian hormone (AMH) and describe the association of AMH with androgenic and metabolic profiles at different ages.

Design:
Cross-sectional study.

Setting:
University hospital.

Patient(s):
A total of 6,763 Chinese women from birth to menopause.

Intervention(s):
None.

Main Outcome Measure(s):
Anthropometric parameters (height, weight, and blood pressure), and levels of AMH and testosterone, glucose metabolism, and lipid profiles.

Result(s):
According to the level of AMH, four age phases were established: childhood (0–10 years), adolescence (11–18 years), reproductive age (19–50 years), and advanced age (≥51 years). During childhood and adolescence, AMH levels increased, reaching a peak at 18 years. A decline occurred thereafter during the reproductive-age period until the age of 50 years, and it remained at a low level above 0 onward. We found that AMH was negatively correlated with testosterone in childhood (r = −0.25), but was positively correlated with testosterone and the free androgen index in adolescence (r = 0.30; r = 0.26, respectively) as well as during the reproductive phases (r = 0.28; r = 0.31, respectively). No correlation was observed between AMH and body mass index, fasting blood glucose, fasting insulin, the homeostasis model assessment, total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein at any phase.

Conclusion(s):
From birth to 18 years, AMH increases, then it declines thereafter, indicating changes of ovarian maintenance. A positive relationship between androgenic profiles and AMH during adolescence and reproductive years implies a synchronism between androgens and ovarian reserve.

Translate »