Is vitrification of oocytes useful for fertility preservation for age related fertility decline and in cancer patients

Vitrification of oocytes is a reproducible, safe, and effective method for fertility preservation in both oncologic and nononcologic patients, with a rapidly increasing demand.

Ana Cobo, Ph.D., Juan A. García Velazco, M.D., Javier Domingo, M.D., José Remohí, M.D., Antonio Pellicer, M.D.

Volume 99, Issue 6, Pages 1485-1495, May 2013


The aim of this review was to update the current knowledge on oocyte cryopreservation, with special emphasis on vitrification as a mean to preserve fertility in different indications. The major advancements achieved in the last few years in the cryo-laboratory have facilitated major changes in our practice. Areas such as fertility preservation for social or oncological reasons, the possibility to create oocyte banks for egg donation programs, the opportunity to avoid ovarian hyperestimulation syndrome, or to accumulate oocyte in low yield patients, or even to offer treatment segmentation by stimulating the ovaries, vitrifying, and then transferring in a natural cycle are some of the options that now open with the development of cryopreservation. We present extensive experience from our group and others on fertility preservation for non-medical reasons as well as in oncological patients, confirming that oocyte vitrification is a standardized, simple, reproducible, and efficient option.

  • Sergio P. Gonçalves

    It is extremely important in cases of ‘social’ FP that patients are counseled not to delay pregnancy just because oocytes or embryos have been criopreserved. This should be an option only for those who are single or have real problems that prevent pregnancy from ocurring in the following years. Patients must be aware that the future IVF treatment might fail, even with a good number of oocytes or embryos. The term ‘preservation’, thus, can be quite misleading and this issue must always be discussed with them.

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