Loop electrosurgical excision procedure and risk of miscarriage

Women with a time interval from LEEP to pregnancy of

Andrea Ciavattini, M.D., Nicolò Clemente, M.D., Giovanni Delli Carpini, M.D., Chiara Gentili, M.D., Jacopo Di Giuseppe, M.D., Pamela Barbadoro, M.D., Emilia Prospero, M.D., Carlo Antonio Liverani, M.D.

Volume 103, Issue 4, Pages 1043-1048


To evaluate the risk of miscarriage in the subsequent pregnancy after a loop electrosurgical excision procedure (LEEP), also considering time elapsed from LEEP to pregnancy.

Multicenter, retrospective cohort study.

Tertiary care university hospitals.

Women who had undergone LEEP from January 2000 to December 2011. Women with histologic assessment of low-grade cervical dysplasia, not requiring subsequent surgical treatment, constituted the control group.


Main Outcome Measure(s):
The first pregnancy after the procedure was evaluated, and only women with singleton spontaneous pregnancies were considered. Women with time intervals of

In women previously treated with LEEP, a total of 116 cases of miscarriage (18.1%) was reported. The mean time interval from LEEP to pregnancy for women with miscarriage compared with women without miscarriage was significantly shorter (25.1 ± 11.7 months vs. 30.1 ± 13.3 months). A higher rate of miscarriage in women with a LEEP-to-pregnancy interval of

Women with a time interval from LEEP to pregnancy of

  • Shvetha Zarek

    It is interesting that in women with a history of LEEP, there was an increased OR of early but not late miscarriage. One would think that there is more risk of cervical insufficiency in later gestations. Was POC from the early miscarriages collected for karyotype analysis to assess aneuploidy status?

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