Biomarkers identified with time lapse imaging Discovery validation and practical application
Time-lapse markers that are supported by basic research, validated through prospective clinical studies, and accompanied by a reliable quantification technology may improve embryo selection and IVF success.
Alice A. Chen, Ph.D., Lei Tan, Ph.D., Vaishali Suraj, M.S., Renee Reijo Pera, Ph.D., Shehua Shen, M.D.
Volume 99, Issue 4, Pages 1035-1043, 15 March 2013
“Time-lapse markers” that are defined by time-lapse imaging and correlated with clinical outcomes may provide embryologists with new opportunities for improving embryo selection. This article provides an overview of non-invasive biomarkers defined by time-lapse imaging studies. In addition to comprehensively reviewing the discovery of each time-lapse marker, it focuses on the criteria necessary for their successful integration into clinical practice, including: 1) statistical and biological significance, 2) validation through prospective clinical studies, and 3) development of reliable technology to measure and quantify the time-lapse marker. Because manual analysis of time-lapse images is labor intensive and limits practical use of image data in the clinic, automated image analysis software platforms may contribute substantially to improvements in embryo selection accuracy. Ultimately, time-lapse markers that are based on a foundation of basic research, validated through prospective clinical studies, and enabled by a reliable quantification technology may improve IVF success rates, encourage broader adoption of single embryo transfer, and reduce the risks associated with multiple gestation pregnancies.