Childhood implications of parental aging

Capsule:
We discuss how societal changes have led to increasing parental age with potential impact on childhood health. The differences in gamete biology may be keys to understanding these risks.

Authors:
Marcelle I. Cedars, M.D.

Volume 103, Issue 6, Pages 1379-1380

Abstract:

Men and women are increasingly delaying childbearing to the late 30s, the 40s and beyond. The implications of this societal change on childhood health and well-being have only recently been a focus of research. There are known increased perinatal risks associated with increasing maternal age, while paternal age seems to have a potentially greater negative impact on childhood health. Understanding the mechanisms underlying the aging of sperm and eggs, and how these changes impact offspring, is a critical next step as we work to help patients build healthy families.

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