Hypoxia inducible factor and microvessels in peri implantation endometrium of women with recurrent miscarriage

Wednesday, June 1, 2016
Expression of hypoxia inducible factor 1a and vascularization status in peri-implantation endometrium is altered in the nonconception cycles of women with a history of recurrent miscarriage.

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Magnetic nanoparticles as a new approach to improve the efficacy of gene therapy against differentiated human uterine fibroid cells and tumor initiating stem cells

Wednesday, June 1, 2016
We discuss whether efficient transduction and subsequent elimination of fibroid tumor-initiating stem cells during debulking of tumor cells will aid in completely eradicating the tumor as well as decreasing the likelihood of recurrence.

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Metal accumulation in the human uterus varies by pathology and smoking status

Wednesday, June 1, 2016
The study found that cancerous tissues of female reproductive tissues, uterine polyps, and those collected from women with a history of smoking are characterized by altered metals status.

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Evaluation of intrauterine insemination practices A 1 year prospective study in seven French assisted reproduction technology centers

Wednesday, June 1, 2016
Gonadotropin-releasing hormone antagonist used with multifollicular stimulation allows high delivery rates in intrauterine insemination.

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Depression anxiety and antidepressant treatment in women Association with in vitro fertilization outcome

Wednesday, June 1, 2016
A diagnosis of depression, anxiety, or treatment with antidepressants before an in vitro fertilization cycle had a slight negative association with pregnancy and live birth but not miscarriage.

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Is FMR1 CGG repeat length a predictor of in vitro fertilization stimulation response or outcome

Wednesday, June 1, 2016
FMR1 CGG repeat lengths within the normal range were not independently associated with ovarian stimulation response or assisted reproduction outcomes.

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Evidence based approach to unexplained infertility A systematic review

Wednesday, June 1, 2016
The available literature on the treatment of unexplained infertility reflects the heterogeneity of clinical practice. Adequately powered, randomized trials are needed to directly compare the efficacy of these treatments.

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Impact of female age and nulligravidity on fecundity in an older reproductive age cohort

Wednesday, June 1, 2016
Women experience a significant reduction in fecundity and an increase in the probability of infertility in the late thirties. At any age >30 years, women, who have never conceived before, have a lower probability of conception.

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Proposal for a national registry to monitor women with Turner syndrome seeking assisted reproductive technology

Wednesday, June 1, 2016

Authors:
Angela E. Lin, M.D., Megan F.…

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In vitro fertilization outcomes after fresh and frozen blastocyst transfer in South Asian compared with white women

Wednesday, June 1, 2016
In vitro fertilization outcomes among South Asian women are similar to Caucasian women in frozen embryo transfer cycles and significantly lower in fresh in vitro fertilization cycles.

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Successful slush nitrogen vitrification of human ovarian tissue

Wednesday, June 1, 2016
The histology, ultrastructure, and viability of follicles and stromal cells are better preserved after vitrification of human ovarian cortical strips with slush nitrogen compared with liquid nitrogen.

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Gonadotropin releasing hormone and gonadotropin releasing hormone receptor are expressed at tubal ectopic pregnancy implantation sites

Wednesday, June 1, 2016
This study discusses the expression of gonadotropin-releasing hormone (GnRH) and its receptor at tubal ectopic pregnancy implantation sites, and investigates the role of GnRH and a GnRH antagonist in regulating trophoblastic BeWo cell viability.

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Social determinants of infertility Beyond the obvious

Wednesday, June 1, 2016
Reflections on "Predictors of pregnancy and live-birth in couples with unexplained infertility following ovarian stimulation-intrauterine insemination" by Hansen et al.

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Magnetic resonance imaging structured reporting in infertility

Wednesday, June 1, 2016
The magnetic resonance structured report in infertility defines and proposes a standardized magnetic resonance imaging structured report in patients with infertility to have clinical completeness regarding possible diagnosis and severity.

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Maternal whole grain intake and outcomes of in vitro fertilization

Wednesday, June 1, 2016
Higher pretreatment whole grain intake was related to a higher probability of live birth among women undergoing in vitro fertilization.

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Surrogacy Yes or no

Wednesday, June 1, 2016

Author:
Rene Frydman, M.D.

Volume 105, Issue 6, Page 1445

Abstract:

Why is surrogacy so highly debated as a pertinent solution for women with infertility caused by uterine factors?…

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Age and fertility A social biological balance

Wednesday, June 1, 2016
Reflections on "The impact of female age and nulligravidity on fecundity in an older reproductive age cohort" by Steiner et al.

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Adhesion phenotype manifests an altered metabolic profile favoring glycolysis

Wednesday, June 1, 2016
Adhesion fibroblasts manifested an altered metabolic profile as compared with normal peritoneal fibroblasts, which favors the glycolytic pathway, and is further altered by hypoxia.

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Inequity between male and female coverage in state infertility laws

Wednesday, June 1, 2016
Inequities exist within state insurance laws that mandate coverage for infertility care. Only 8 of 15 state laws include coverage for male partners, placing undue burden on the female partner.

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Ultrasound in assisted reproduction A call to fill the endometrial gap

Wednesday, June 1, 2016
Ultrasound offers descriptive and physiologic assessment of the endometrium. Current prediction of pregnancy by endometrial ultrasound is not satisfactory. Future integration of multiple variables may lead to better prediction.

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Complete evaluation of anatomy and morphology of the infertile patient in a single visit The modern infertility pelvic ultrasound examination

Wednesday, June 1, 2016
The concept of “one-stop shopping” for evaluating female infertility is a comprehensive ultrasound evaluating the uterus and ovaries, including the shape of the cavity, serosal surface, and tubal patency.

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Predictive value of sperm morphology and progressively motile sperm count for pregnancy outcomes in intrauterine insemination

Wednesday, June 1, 2016
In addition to female factors, a low percentage of morphologically normal spermatozoa and moderate number of inseminated motile spermatozoa have a positive predictive value for successful intrauterine insemination, albeit low.

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Triple X syndrome and puberty Focus on the hypothalamus hypophysis gonad axis

Wednesday, June 1, 2016
This study of the hypothalamus-hypophysis-gonad axis in children and adolescents with nonmosaic triple X syndrome found that Triple X patients showed premature activation of the gonadotropin-releasing hormone pulse generator and reduced gonadal function.

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Two dimensional and three dimensional imaging of uterus and fallopian tubes in female infertility

Wednesday, June 1, 2016
Noninvasive imaging techniques play an important role in the female infertility diagnostic algorithm. Computerized tomographic and magnetic resonance virtual hysterosalpingography techniques allow a comprehensive assessment of the female reproductive system.

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Clinical hormonal ovarian and genetic aspects of 46 XX patients with congenital adrenal hyperplasia due to CYP17A1 defects

Wednesday, June 1, 2016
P450c17 deficiency due to inactivating CYP17A1 mutation in 46,XX patients is associated with primary or secondary amenorrhea, absent/sparse pubic hair, hypertension, and high prevalence of ovarian macrocysts with a risk of torsion. In patients with hypergonadotropic hypogonadism, high basal progesterone level is a hallmark for this diagnosis.

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Validation of a next generation sequencing based protocol for 24 chromosome aneuploidy screening of blastocysts

Wednesday, June 1, 2016
Our study validated multiple annealing and looping-based amplification cycle next-generation sequencing for 24-chromosome aneuploidy screening of blastocysts.

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Social and ethical implications of fertility preservation

Wednesday, June 1, 2016

Authors:
Robert W. Rebar, M.D.…

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Interaction of apolipoprotein E gene polymorphisms on miscarriage risk in black and white American women

Wednesday, June 1, 2016
We investigated a biracial cohort of women at the end of their reproductive life. Carrying the apolipoprotein E*2 allele was a risk factor for pregnancy loss only in white women.

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Imaging and angiography in male factor infertility

Wednesday, June 1, 2016
Ultrasound imaging and angiography techniques play a crucial role in the diagnosis and treatment of men with subfertility.

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Every last baby out of every last egg The appropriate goal for fertility treatment in women older than 40 years

Wednesday, June 1, 2016

Authors:
Richard J. Paulson, M.D.…

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