Luteal phase support for frozen embryo transfer cycles Intramuscular or vaginal progesterone

Capsule:
This editorial focuses on frozen embryo transfer (FET) or donor oocyte embryo transfer where hormonal therapy is used for endometrial preparation and no functional corpus luteum is present.

Author:
Robert F. Casper, M.D.

Volume 101, Issue 3, Pages 627-628, March 2014

Abstract:

This editorial focuses on frozen embryo transfer (FET) or donor oocyte embryo transfer where hormonal therapy is used for endometrial preparation and no functional corpus luteum is present.

  • Ivan-Martín Valencia

    Pregnancy rates in the US are much higher than in Europe, specially during oocyte donation and frozen thawed embryo transfer. A common feature in US center is the use of IM progesterone instead of the European approach to vaginal progesterone. Dr Casper suggests that IM P4 the first part of the luteal phase support enhances outcome. Could it be possible that vaginal progesterone does not absorbs quick enough after initial application to produce an effect at the myometrial/endometrial level?

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