A historical perspective of aromatase inhibitors for ovulation induction
This review provides a brief history of the development of letrozole for ovulation induction.
Robert F. Casper, M.D. and Mohamed F. M. Mitwally, M.D., H.C.L.D.
Volume 98, Issue 6, Pages 1352-1355, December 2012
The concept of using aromatase inhibitors in place of clomiphene citrate (CC) for ovulation induction was introduced more than 10 years ago and a brief history of its development is presented. Worldwide usage for ovulation induction, and as an adjunct for intrauterine insemination and in vitro fertilization has occurred despite the absence of definitive data of superiority to CC. The results of two ongoing potentially definitive multicenter trials of efficacy and safety of letrozole compared to CC are eagerly awaited.