The aging oocyte Can mitochondrial function be improved

We describe the role of mitochondrial dysfunction in ovarian senescence and suggest a treatment to improve reproductive outcome with mitochondrial nutrients.

Yaakov Bentov M.D. and Robert F. Casper, M.D.

Volume 99, Issue 1, Pages 18-22, January 2013


In recent years women have been delaying childbirth due to social and cultural trends, thereby increasing the significance of reproductive senescence as a public health problem. In this paper we discuss potential etiologies for age related female reproductive decline. We bring supportive evidence to the central role of mitochondrial dysfunction and oxygen radicals in the process of aging in general and reproductive senescence specifically. We also explore the role of Coenzyme Q10 deficiency as a contributing factor and the effects of its administration.

  • Brittney

    I was wondering: The article states, near the end, “an increase in the number of ovulated eggs, after stimulation.” Does this mean IVF? Or other medical intervention to help stimulate ovulation?
    I am curious because my husband and I are not going through any medical interventions to conceive (although we have been pregnant twice, with 2 losses, at 6 and 9 weeks). We want to conceive naturally (no money to go through IVF). Adding Ubiquinol makes sense, as long as there is a possibility that it will help me, without the stimulation of my eggs, by medications, etc. I hope this question and reasoning behind it makes sense!
    Thank you for responding ASAP.

  • Micah Hill

    Thank you for the very nice review on mitochondria and the aging oocyte. Do you know how long oral CoQ10 needs to be supplemented in women before a benefit might be seen in the oocytes?

    • Hi Micah,
      We don’t know for sure but we believe it may take about 2 months based on our mouse research that will be submitted for publication shortly.



      • Micah Hill

        Thank you for the reply. That seems like a very reasonable treatment period to be able to enroll patients in RCT prior to treatment.

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