Does the level of serum antimullerian hormone predict ovulatory function in women with Polycystic Ovary Syndrome with aging

Capsule:
Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.

Authors:
Enrico Carmina, M.D., Anna Maria Campagna, M.D., Pasquale Mansuet, M.D., Giustina Vitale, M.D., Daniel Kort, M.D., Roger Lobo, M.D.

Volume 98, Issue 4, Pages 1043-1046, October 2012

Abstract:

Objective:
To determine possible prediction of regular menses with aging in anovulatory women with PCOS.

Design:
Cohort.

Setting:
Academic practice.

Patients:
A total of 54 anovulatory women with PCOS and 28 age- and weight-matched controls.

Interventions:
Blood and ovarian ultrasound at baseline and after 5 years.

Major Outcome Measures:
Serum AMH, gonadotropins, androgens, insulin sensitivity, AMH, and ovarian ultrasound.

Results:
After 5 years, there was a significant decrease in AMH in women with PCOS and controls. (Ten of 54 anovulatory women became ovulatory after 5 yrs.) There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH (< 4ng/ml) was associated with ovulatory function. Conclusion:
Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.

  • Alberto Pacheco Castro

    It is a very interesting article. I agree with the authors that the measurements of serum AMH can provide useful clinical information in these group of patients. Perhaps, you will obtain a more consistent predictive AMH value by increasing the number of patients in the PCOS group who became ovulatory. Regarding the change to the new AMH ELISA Kit, that I also use, I have one question: Has the cutoff value changed with the new AMH kit, or remain at 4 ng/mL ? Thank you, and congratulations for your work!

  • laurenwroth

    This is a nice study that followed a cohort of women with PCOS over 5 years and looked at changes in hormonal parameters and association with ovulation. I think the results give some useful information for counseling a patient with PCOS who is later in her reproductive years. I think this study should be expanded to include women starting in their 20’s to offer even more useful information for counseling patients.

Translate »