Does the level of serum antimullerian hormone predict ovulatory function in women with Polycystic Ovary Syndrome with aging

Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.

Enrico Carmina, M.D., Anna Maria Campagna, M.D., Pasquale Mansuet, M.D., Giustina Vitale, M.D., Daniel Kort, M.D., Roger Lobo, M.D.

Volume 98, Issue 4, Pages 1043-1046, October 2012


To determine possible prediction of regular menses with aging in anovulatory women with PCOS.


Academic practice.

A total of 54 anovulatory women with PCOS and 28 age- and weight-matched controls.

Blood and ovarian ultrasound at baseline and after 5 years.

Major Outcome Measures:
Serum AMH, gonadotropins, androgens, insulin sensitivity, AMH, and ovarian ultrasound.

After 5 years, there was a significant decrease in AMH in women with PCOS and controls. (Ten of 54 anovulatory women became ovulatory after 5 yrs.) There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH (< 4ng/ml) was associated with ovulatory function. Conclusion:
Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS.

  • Alberto Pacheco Castro

    It is a very interesting article. I agree with the authors that the measurements of serum AMH can provide useful clinical information in these group of patients. Perhaps, you will obtain a more consistent predictive AMH value by increasing the number of patients in the PCOS group who became ovulatory. Regarding the change to the new AMH ELISA Kit, that I also use, I have one question: Has the cutoff value changed with the new AMH kit, or remain at 4 ng/mL ? Thank you, and congratulations for your work!

  • laurenwroth

    This is a nice study that followed a cohort of women with PCOS over 5 years and looked at changes in hormonal parameters and association with ovulation. I think the results give some useful information for counseling a patient with PCOS who is later in her reproductive years. I think this study should be expanded to include women starting in their 20’s to offer even more useful information for counseling patients.

Translate »