Insulin resistance and its relationship with high molecule weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history

Capsule:
Normal weight adolescents with PCOS and a maternal history of PCOS had a significantly increased rate of insulin resistance independent of body mass index and inversely correlated with high molecular weight adiponectin.

Authors:
Sevil Cankaya, M.D., Berfu Demir, M.D., Sezin Erturk Aksakal, M.D., Berna Dilbaz, M.D., Canan Demirtas, Ph.D., Umit Goktolga, M.D.

Volume 102, Issue 3, Pages 826-830

Abstract:

Objective:
To assess the rate of insulin resistance (IR) and the relationship between IR and high molecular weight (HMW) adiponectin in normal weight adolescents with polycystic ovary syndrome (PCOS) and a maternal history of PCOS.

Design:
Case-controlled study.

Setting:
Adolescent clinic of a teaching and research hospital.

Patient(s):
Forty normal weight adolescents with PCOS and a maternal history of PCOS and 40 normo-ovulatory age- and body mass index (BMI)-matched controls.

Intervention(s):
A 75-g oral glucose tolerance test (OGTT) was performed for each participant.

Main Outcome Measure(s):
Homeostasis model assessment of IR and HMW adiponectin.

Result(s):
There were no statistically significant differences between the PCOS and control groups in terms of fasting glucose, fasting insulin, and lipid parameters. Although total and free T were significantly higher, HMW adiponectin levels were significantly lower in the PCOS group compared with the control group. When the PCOS group was compared according to the IR, the HMW adiponectin level was significantly lower in the adolescents with PCOS and IR. The adolescents with PCOS and biochemical hyperandrogenemia had significantly lower HMW adiponectin levels and significantly higher homeostasis model assessment of IR score compared with the adolescents with PCOS and normoandrogenemia.

Conclusion(s):
The adolescents with PCOS had a significantly increased rate of IR without clinical findings of metabolic disorders or obesity. The HMW adiponectin levels were negatively correlated with IR.

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