Endometriosis may not be a chronic disease An alternative theory offering more optimistic prospects for our patients

Michel Canis, M.D., Ph.D., Nicolas Bourdel, M.D., Céline Houlle, M.D., Anne Sophie Gremeau, M.D., Revaz Botchorishvili, M.D., Sachiko Matsuzaki, M.D.

Volume 105, Issue 1, Pages 32-34


For more than a century, endometriosis has been described as unexplained, poorly understood, or enigmatic. As a result treatments are not based on the pathophysiology of the disease, which consequently cannot be cured effectively, meaning that the symptoms, which have major consequences on women’s quality of life, will almost inevitably recur. Such pessimistic perspectives have devastating consequences, particularly on the results of treatments for chronic pelvic pain. All the mechanisms proposed, whether retrograde menstruation, metaplasia, lymphatic and vascular metastasis, embryology, stem cells, and müllerianosis, may occur in all women.

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