Ovarian stimulation in cancer patients

When performing ovarian stimulation for fertility preservation in cancer patients it is critical to understand time constraints, potential complications, risks, and the limited time opportunity.

Hakan Cakmak, M.D., Mitchell P. Rosen, M.D.

Volume 99, Issue 6, Pages 1476-1484, May 2013


The patients referred for fertility preservation due to a malignant disease do not represent the typical population of subfertile patients treated in the in vitro fertilization units. Cancer may affect multiple tissues throughout the body and can result in variety of complications during controlled ovarian stimulation. Determination of the controlled ovarian stimulation protocol and gonadotropin dose for oocyte/embryo cryopreservation requires an individualized assessment. In this review, we highlight the new protocols that are emerging to reduce time constraints and emphasize management considerations to decrease complications.

  • Javier Domingo del Pozo

    Congratulations! It’s a nice and complete review of the different protocols for COS. And important the comments of the different complications that can appear, as they can turn a prophylactic treatment in an awkward situation. Respect the stimulation protocols starting in the luteal phase, I think they are the solution for the frequent lack of time before starting chemotherapy, as it would be usually delayed less than two weeks (oncologists should know this), but data of warmed oocytes and pregnancies obtained are missed.

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