Role of spermatozoa in the etiology of miscarriage

Richard Bronson, M.D.

Volume 105, Issue 1, Pages 47-48

Reflections on “Relationship between sperm aneuploidy, sperm DNA integrity, chromatin packaging, traditional semen parameters and recurrent pregnancy loss” by Zidi-Jrah et al.


    We agree that damaged sperm that are beyond repair play a significant role in miscarriage. The difficulty lies in determining the severity of sperm nuclear damage. Recently, we developed a simple test to expose and analyze the sperm DNA toroids showing a correlation between damaged sperm nucleus and miscarriage:
    As mentioned, correlation is not evidence of causation, but many such correlations make a compelling conclusion.

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