Blastocyst collapse is not an independent predictor of reduced live birth A time lapse study

Capsule:
Blastocyst collapse observed by time-lapse monitoring is not independently associated with a decreased chance of live birth; rather it is confounded by morphokinetic parameters that are stronger predictors of reproductive outcome.

Authors:
Daniel Bodri, M.D., M.Sc., Ph.D., Takeshi Sugimoto, M.Sc., Jazmina Yao Serna, M.Sc., Satoshi Kawachiya, M.D., Ryutaro Kato, B.Sc., Tsunekazu Matsumoto, M.D., Ph.D.

Volume 105, Issue 6, Pages 1476-1483

Abstract:

Objective:
To ascertain the rate of blastocyst collapse observed by time-lapse monitoring in a retrospective cohort of unselected infertile patients undergoing single blastocyst transfer and to determine its association with live birth.

Design:
Blastocyst collapse and morphokinetic variables were scored according to previously published criteria. The association between blastocyst collapse and live birth was evaluated by a multivariate logistic regression analysis including morphokinetic variables and other confounders.

Setting:
Private infertility clinic.

Patient(s):
Patients who underwent 277 consecutive single blastocyst transfers (mean age, 38.4 ± 3.9 years; range, 28–47 years) after minimal ovarian stimulation.

Intervention(s):
Minimal ovarian stimulation, prolonged embryo culture in time-lapse monitoring incubator, elective vitrification with subsequent vitrified-warmed single blastocyst transfer.

Main Outcome Measure(s):
Live birth rate per single blastocyst transfer in different blastocyst collapse groups (no, single, multiple collapses).

Result(s):
No, single, or multiple blastocyst collapses occurred in 54% (150/277), 22% (61/277), and 24% (66/277) of the cohort, respectively. In the multiple collapse group on average 2.9 contractions were seen (range, 2–9 contractions). Live birth rate decreased progressively between blastocyst collapse groups (36%, 31%, 14%); significantly lower if multiple collapses occurred. In a multivariate analysis, however, blastocyst collapse was not found to be a significant predictor and was confounded by stronger predictors such as morphokinetic variables t2, texpB2, and female age.

Conclusion(s):
Blastocyst collapse pattern should not be evaluated alone without taking into account morphokinetic variables that are stronger predictors of reproductive outcome.

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