Each small antral follicle in ovaries of women with polycystic ovary syndrome produces more antimullerian hormone than its counterpart in a normal ovary An observational cross sectional study

Capsule:
An observational cross-sectional study showed that subfertile women with polycystic ovary syndrome secrete significantly more antimullerian hormone per antral follicle than women with polycystic ovarian morphology only and control women.

Authors:
Priya Bhide, M.R.C.O.G., Merve Dilgil, M.Sc., Anil Gudi, M.R.C.O.G., Amit Shah, M.R.C.O.G., Charity Akwaa, B.Sc., Roy Homburg, F.R.C.O.G.

Volume 103, Issue 2, Pages 537-541

Abstract:

Objective:
To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women.

Design:
Observational cross-sectional study.

Setting:
Fertility clinic.

Patient(s):
A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013.

Intervention(s):
Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria.

Main Outcome Measure(s):
The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control.

Result(s):
The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status.

Conclusion(s):
Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.

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