Obesity reduces uterine receptivity clinical experience from 9587 first cycles of ovum donation with normal weight donors

Capsule:
Female obesity impairs the reproductive outcome of ovum donation by reducing uterine receptivity.

Authors:
José Bellver, M.D., Antonio Pellicer, M.D., Juan Antonio García-Velasco, M.D., Agustín Ballesteros, M.D., José Remohí, M.D., Marcos Meseguer, Ph.D.

Volume 100, Issue 4, Pages 1050-1058.e2, October 2013

Abstract:

Objective:
To analyze the reproductive outcome of recipients of donated ova according to their body mass index (BMI).

Design:
Twelve-year retrospective cohort analysis.

Setting:
Fertility clinics.

Patient(s):
9,587 first cycles of ovum donation with ova from normoweight donors.

Intervention(s):
Recipients divided according to their BMI to analyze IVF laboratory and outcome parameters: lean with BMI <20 kg/m2 (n = 1,458; 15.2%); normoweight with BMI 20–24.9 kg/m2 (n = 5,706; 59.5%), overweight with BMI 25–29.9 kg/m2 (n = 1,770; 18.5%), and obese with BMI ≥30 kg/m2 (n = 653; 6.8%). Main Outcome Measure(s):
Implantation, biochemical and clinical pregnancy, miscarriage, and live-birth rates.

Result(s):
In vitro fertilization laboratory parameters did not differ according to BMI. However, implantation, pregnancy, clinical pregnancy, twin pregnancy, and live-birth rates were significantly reduced as BMI increased. In the lean, normoweight, overweight, and obese groups, the implantation rate was 40.4%, 39.9%, 38.5%, and 30.9%, clinical pregnancy rate was 56.9%, 55.9%, 54.3%, and 45.3%, and live-birth rate was 38.6%, 37.9%, 34.9%, and 27.7%, respectively. However, clinical miscarriage rates were similar in all the groups.

Conclusion(s):
Female obesity impairs the reproductive outcome of ovum donation probably as a result of reduced uterine receptivity.

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